chronic inflammation

pathology

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Last updated

July 21, 2026

Quick Summary

Chronic inflammation is a prolonged response triggered by tissue damage, distinct from acute inflammation which resolves quickly. It occurs when the body's defense mechanisms fail to eliminate an injurious agent or repair damaged tissue, leading to persistent inflammation.12

Causes can include persistent infections, exposure to irritants like silica dust, or autoimmune reactions where the immune system attacks the body's own tissues. Chronic inflammation is characterized by the infiltration of macrophages, lymphocytes, and plasma cells.1

This prolonged inflammatory state can contribute to various diseases, such as tuberculosis and rheumatoid arthritis. It can also result from chronic stress, negatively impacting immunity and increasing the risk of conditions like heart disease and diabetes.134

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inflammation
Chronic inflammation
If the agent causing an inflammation cannot be eliminated, or if there is some interference with the healing process, an acute inflammatory response may progress to the chronic stage. Repeated episodes of acute inflammation also can give rise to chronic inflammation. The physical…
Read More
If the agent causing an inflammation cannot be eliminated, or if there is some interference with the healing process, an acute inflammatory response may progress to the chronic stage. Repeated episodes of acute inflammation also can give rise to chronic inflammation. The physical…
Read More