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carbamoylaspartate
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carbamoylaspartate

chemical compound
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Quick Summary

Carbamoylaspartate is a chemical compound involved in metabolic pathways, specifically in the biosynthesis of pyrimidine nucleotides. It is formed in a reaction catalyzed by aspartate carbamoyltransferase, which initiates a sequence of reactions leading to pyrimidine nucleotides like UTP and CTP. The activity of aspartate carbamoyltransferase is regulated by other molecules. For instance, CTP can decrease the enzyme's affinity for its substrate, aspartate, thereby inhibiting the pathway. Conversely, ATP, a purine nucleotide, can relieve this inhibition. This regulatory mechanism helps coordinate the production of nucleic acid precursors.1

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2 Britannica Sources
  1. metabolism - End-product inhibition
  2. metabolic disease - Urea cycle defects

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