carbamoyl phosphate
Quick Summary
Carbamoyl phosphate is a chemical compound that plays a crucial role in the biosynthesis of pyrimidine nucleotides, which are essential building blocks for RNA and DNA. It is formed from carbon dioxide, ATP, and ammonia.1
In the synthesis of pyrimidine nucleotides, carbamoyl phosphate condenses with aspartate to form N-carbamoylaspartate. This compound then undergoes further reactions, including oxidation and the addition of a pentose phosphate moiety, ultimately leading to the formation of uridylic acid (UMP), a primary pyrimidine nucleotide. UMP can then be converted to other pyrimidine nucleotides like CTP, which are vital for cellular functions.1
Ask Britannica AI about this topic
Britannica doesn't have a full article on this topic, so we've curated a list of our relevant coverage.
metabolismDisposal of nitrogen…dioxide and ATP to form carbamoyl phosphate, ADP, and inorganic phosphate, as shown in reaction [30].
Read More…dioxide and ATP to form carbamoyl phosphate, ADP, and inorganic phosphate, as shown in reaction [30].
Read More- metabolismPyrimidine ribonucleotides
…TCA cycle intermediate, oxaloacetate) and carbamoyl phosphate (derived from carbon dioxide, ATP, and ammonia via reaction [30]) condense to form N-carbamoylaspartate (reaction [70]), which loses water in a reaction ([71]) catalyzed by dihydroorotase.
Read More…TCA cycle intermediate, oxaloacetate) and carbamoyl phosphate (derived from carbon dioxide, ATP, and ammonia via reaction [30]) condense to form N-carbamoylaspartate (reaction [70]), which loses water in a reaction ([71]) catalyzed by dihydroorotase.
Read More