calcium pyrophosphate crystals deposition

Calcium pyrophosphate crystal deposition disease (CPPD), also known as pseudogout, is a metabolic disorder that causes joint inflammation. It occurs when rhomboid-shaped calcium pyrophosphate crystals deposit in the joint space.1

This condition can lead to symptoms that mimic gout, including joint pain and inflammation. It most commonly affects one or two joints, such as the knee, ankles, wrists, or shoulders, and can last from a day to several weeks.1

While the exact cause is not always clear, elevated levels of pyrophosphate in the joint fluid are a major contributing factor. This can be due to cellular injury from trauma, surgery, or illness, or a deficiency in alkaline phosphatase, an enzyme that breaks down pyrophosphate. Other associated disorders include hyperparathyroidism and hypothyroidism. CPPD affects both men and women, with a higher incidence in older adults.1