calcitrial

Calcitriol is the most potent derivative of vitamin D and is crucial for calcium metabolism in animals. It is produced in the kidneys from calcidiol, which is formed in the liver from vitamin D precursors like ergocalciferol (vitamin D2) and cholecalciferol (vitamin D3).1

Calcitriol, along with parathyroid hormone (PTH), plays a vital role in maintaining blood calcium levels. It increases the absorption of dietary calcium in the small intestine and works with PTH to stimulate bone cells (osteoblasts) to promote the formation of osteoclasts, which release calcium and phosphorus into the bloodstream. This process is essential for proper bone mineralization and overall calcium-phosphate equilibrium in the body. A deficiency in vitamin D, and consequently calcitriol, can lead to rickets in children and osteomalacia in adults due to poor calcium absorption and bone mineralization.21