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The brush border is a layer of microvilli found on the surface of certain epithelial cells, most notably those lining the kidney tubules and the small intestine. These microvilli are tiny, bristle-like protrusions that significantly increase the surface area of the cell.12

In the small intestine, the brush border plays a crucial role in digestion and absorption. It enlarges the absorptive surface area of the intestinal lining by about 25 times, facilitating the uptake of nutrients and water. The microvilli also secrete enzymes like disaccharidase and peptidase, which break down complex carbohydrates and proteins into simpler forms that can be absorbed. This specialized structure is essential for efficient nutrient absorption in the digestive system.32

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