bancroftian filariasis

Bancroftian filariasis is a disease caused by the nematode Wuchereria bancrofti. This parasitic worm infects the lymphatic system, primarily in tropical and subtropical regions.1

The infection cycle involves mosquitoes as intermediate hosts. Female worms produce microfilariae, which are ingested by mosquitoes during a blood meal. These microfilariae develop into infective larvae within the mosquito and are transmitted to humans during subsequent bites. In humans, the larvae mature into adult worms, which reside in lymph nodes and vessels, particularly in the legs and genital area.1

Over time, the adult worms can cause inflammation, swelling, and hardening of the lymph channels. In severe, untreated cases, this can lead to elephantiasis, characterized by significant tissue enlargement, most commonly in the legs and scrotum. Diethylcarbamazine is an effective drug for treating Bancroftian filariasis.12