ataxia-telangiectasia

Ataxia-telangiectasia is an inherited systemic disorder characterized by progressive pathological changes in the nervous system. This leads to a loss of motor coordination, a condition known as ataxia, which is the inability to coordinate voluntary muscular movements. Individuals with ataxia-telangiectasia also experience increased susceptibility to cancer, particularly of the lymphoid tissue. The disorder typically manifests with an unsteady gait, which worsens over time, and can also involve tremors, slurred speech, and skeletal deformities.12