aspartate
Quick Summary
Aspartate is a salt or ester of aspartic acid, which is an amino acid. Aspartic acid is one of the nonessential amino acids for mammals, meaning they can synthesize it. It is also classified as an acidic amino acid due to a carboxylic acid group on its side chain, giving it acidic properties. In aqueous solutions at physiological pH, aspartic acid is ionized and referred to as aspartate. Aspartate and glutamate side chains can form ionic bonds and are found in proteins that bind metal ions. Aspartic acid is also a component in the synthesis of the sweetener aspartame.1234
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metabolismRemoval of nitrogen… (NH3) can be removed from aspartate via a reaction catalyzed by aspartase [27]; the other product, fumarate, is an intermediate of the TCA cycle.
Read More… (NH3) can be removed from aspartate via a reaction catalyzed by aspartase [27]; the other product, fumarate, is an intermediate of the TCA cycle.
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metabolismPyrimidine ribonucleotidesAspartate (derived from the TCA cycle intermediate, oxaloacetate) and carbamoyl phosphate (derived from carbon dioxide, ATP, and ammonia via reaction [30]) condense to form N-carbamoylaspartate (reaction [70]), which loses water in a reaction ([71]) catalyzed by dihydroorotase.
Read MoreAspartate (derived from the TCA cycle intermediate, oxaloacetate) and carbamoyl phosphate (derived from carbon dioxide, ATP, and ammonia via reaction [30]) condense to form N-carbamoylaspartate (reaction [70]), which loses water in a reaction ([71]) catalyzed by dihydroorotase.
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