aromatase

enzyme

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Last updated

July 19, 2026

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Aromatase is an enzyme that plays a crucial role in the conversion of androgens (male sex hormones) into estrogens (female sex hormones). This process is essential for the development and function of the reproductive systems in both males and females, although estrogens are primarily associated with female characteristics. The ovaries are a primary source of aromatase, but it is also found in other tissues like adipose tissue. This enzymatic conversion is a key step in the synthesis of various estrogenic hormones, including estradiol and estrone.12

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estrogen
Synthesis and secretion of estrogen
…of an enzyme known as aromatase. The ovaries are the richest source of aromatase, although some aromatase is present in adipose tissue, which is also an important source of estrogen in postmenopausal women. Estradiol, the most potent estrogen, is synthesized from testosterone. Estrone can be formed from estradiol, but its…
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…of an enzyme known as aromatase. The ovaries are the richest source of aromatase, although some aromatase is present in adipose tissue, which is also an important source of estrogen in postmenopausal women. Estradiol, the most potent estrogen, is synthesized from testosterone. Estrone can be formed from estradiol, but its…
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letrozole
…specifically targets an enzyme called aromatase, which catalyzes the formation of estrogens from androgens, such as testosterone. For this reason, letrozole belongs to a larger group of drugs known as aromatase inhibitors, many of which are potent agents used primarily for the treatment of cancers that depend on estrogens to…
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…specifically targets an enzyme called aromatase, which catalyzes the formation of estrogens from androgens, such as testosterone. For this reason, letrozole belongs to a larger group of drugs known as aromatase inhibitors, many of which are potent agents used primarily for the treatment of cancers that depend on estrogens to…
Read More