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argininosuccinic acid synthetase
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argininosuccinic acid synthetase

chemical compound
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Quick Summary

Argininosuccinic acid synthetase is an enzyme that catalyzes a step in the urea cycle. This cycle is crucial for mammals, fish, and amphibians to detoxify ammonia, a byproduct of amino acid breakdown, by converting it into urea for excretion.12

The enzyme facilitates the reaction between citrulline and aspartate to form argininosuccinate. This process is part of a larger metabolic pathway that ensures nitrogenous waste is safely removed from the body, preventing toxic ammonia buildup. Defects in the urea cycle can lead to serious health issues, including neurological impairment.123

Summary created from Britannica articles using AI. AI can make mistakes, so verify using Britannica articles.
2 Britannica Sources
  1. metabolic disease - Urea cycle defects
  2. metabolism - Disposal of nitrogen

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