angiotensinogen

biochemistry

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Last updated

July 23, 2026

Quick Summary

Angiotensinogen is a protein produced by the liver that is essential for regulating blood pressure. The kidneys release an enzyme called renin, which acts on angiotensinogen to create angiotensin I. This is then converted into angiotensin II by angiotensin-converting enzyme (ACE). Angiotensin II causes blood vessels to constrict, increasing blood pressure. It also stimulates the release of aldosterone from the adrenal glands, which promotes salt and water reabsorption by the kidneys, further raising blood pressure. Drugs that block ACE or angiotensin II receptors are used to treat hypertension.12

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adrenal gland
Regulation of adrenal hormone secretion
…a plasma protein called angiotensinogen into a decapeptide (consisting of 10 amino acids) called angiotensin I. An enzyme in the serum called angiotensin-converting enzyme (ACE) then converts angiotensin I into an octapeptide (consisting of eight amino acids) called angiotensin II. Angiotensin II acts via specific receptors
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…a plasma protein called angiotensinogen into a decapeptide (consisting of 10 amino acids) called angiotensin I. An enzyme in the serum called angiotensin-converting enzyme (ACE) then converts angiotensin I into an octapeptide (consisting of eight amino acids) called angiotensin II. Angiotensin II acts via specific receptors
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aldosterone
…circulating in the plasma called angiotensinogen, cleaving this substance into angiotensin I. Angiotensin I is subsequently converted to angiotensin II, which stimulates the release of aldosterone from the adrenal glands.
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…circulating in the plasma called angiotensinogen, cleaving this substance into angiotensin I. Angiotensin I is subsequently converted to angiotensin II, which stimulates the release of aldosterone from the adrenal glands.
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renin-angiotensin system
…of a plasma protein called angiotensinogen into a decapeptide (consisting of 10 amino acids) called angiotensin I. An enzyme in the serum called angiotensin-converting enzyme (ACE) then converts angiotensin I into an octapeptide (consisting of eight amino acids) called angiotensin II. Angiotensin II acts via
Read More
…of a plasma protein called angiotensinogen into a decapeptide (consisting of 10 amino acids) called angiotensin I. An enzyme in the serum called angiotensin-converting enzyme (ACE) then converts angiotensin I into an octapeptide (consisting of eight amino acids) called angiotensin II. Angiotensin II acts via
Read More