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angiotensin converting enzyme inhibitor

drug
Also known as: ACE inhibitor

Quick Summary

ACE inhibitors are a class of drugs used to treat hypertension (high blood pressure). They work by inhibiting the activity of angiotensin converting enzyme (ACE). The renin-angiotensin system is a physiological system that regulates blood pressure. In this system, renin, an enzyme secreted by the kidneys, catalyzes the conversion of angiotensinogen into angiotensin I. ACE then converts angiotensin I into angiotensin II, a potent vasoconstrictor that increases blood pressure. By blocking the formation of angiotensin II, ACE inhibitors relax arteries and promote the excretion of salt and water, thereby lowering blood pressure. Captopril is an example of an ACE inhibitor.123

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