amyloid precursor protein
Quick Summary
The amyloid precursor protein (APP) is a normal component of nerve cells. In Alzheimer's disease, APP is involved in the formation of amyloid beta, a sticky protein that clumps together to form plaques in the brain. These plaques are a hallmark of Alzheimer's disease and are believed to disrupt normal brain function, leading to the destruction of nerve cells and a decline in cognitive abilities. While the exact role of APP and amyloid beta in the disease process is still being researched, genetic mutations in the APP gene can increase the production or deposition of amyloid beta, contributing to the disease.12
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Alzheimer diseaseNeuritic plaques and neurofibrillary tangles…from a larger molecule called amyloid precursor protein, which is a normal component of nerve cells. Neurofibrillary tangles are twisted protein fibres located within nerve cells. These fibres consist of a protein, called tau, that normally occurs in neurons. When incorrectly processed, tau molecules clump together and form tangles.
Read More…from a larger molecule called amyloid precursor protein, which is a normal component of nerve cells. Neurofibrillary tangles are twisted protein fibres located within nerve cells. These fibres consist of a protein, called tau, that normally occurs in neurons. When incorrectly processed, tau molecules clump together and form tangles.
Read More- Alzheimer diseaseGenetic variants
…in a gene known as APP, which codes for amyloid precursor protein, may increase the production or deposition of amyloid beta, which forms the core of neuritic plaques. This gene, however, is thought to be responsible for only a very small percentage of all early-onset cases of the disease.
Read More…in a gene known as APP, which codes for amyloid precursor protein, may increase the production or deposition of amyloid beta, which forms the core of neuritic plaques. This gene, however, is thought to be responsible for only a very small percentage of all early-onset cases of the disease.
Read More