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In genetics, allele frequency refers to the ratio of a specific allele's occurrences within a population compared to the total number of alleles at that genetic locus. This measurement is a fundamental tool in population genetics, used to describe the genetic makeup of populations and understand evolutionary changes.1234

Allele frequencies can change over time due to various factors, including mutation, natural selection, and genetic drift. Mutation is the ultimate source of new genetic variation, but it typically changes allele frequencies very slowly. Natural selection favors certain alleles over others based on environmental conditions, leading to shifts in frequency. Genetic drift, particularly in smaller populations, can cause random fluctuations in allele frequencies. The study of these changes is central to understanding evolution.2354

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