aconitase

enzyme

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July 23, 2026

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Aconitase is an enzyme that plays a crucial role in the tricarboxylic acid (TCA) cycle, a fundamental part of cellular respiration. This cycle occurs in the mitochondria of most living cells and is responsible for breaking down fuel molecules like glucose into carbon dioxide and energy. Aconitase catalyzes the isomerization of citrate to isocitrate, a key step in this metabolic pathway. The TCA cycle ultimately generates energy in the form of ATP, which powers cellular functions. Aconitate itself can also refer to a salt or ester of aconitic acid.123

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metabolism
Formation of coenzyme A, carbon dioxide, and reducing equivalent
…and isocitrate—remain closely associated with aconitase, the enzyme that catalyzes the isomerization process, and that most of the cis-aconitate is not released from the enzyme surface but is immediately converted to isocitrate.
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…and isocitrate—remain closely associated with aconitase, the enzyme that catalyzes the isomerization process, and that most of the cis-aconitate is not released from the enzyme surface but is immediately converted to isocitrate.
Read More