acetyl coenzyme A carboxylase

enzyme

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July 23, 2026

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Acetyl coenzyme A carboxylase (ACC) is an enzyme crucial for fatty acid synthesis. It catalyzes the carboxylation of acetyl coenzyme A to form malonyl coenzyme A, using biotin as a prosthetic group and requiring ATP. This reaction is the initial, energy-requiring step in building fatty acids from acetyl coenzyme A, which is derived from carbohydrate and fatty acid breakdown. The process involves several enzymatic steps, ultimately leading to the formation of longer fatty acid chains like palmitic acid. Acetyl coenzyme A itself is a key metabolic intermediate involved in biological acetylations.12

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metabolism
Fatty acids
…carboxylation reaction is catalyzed by acetyl CoA carboxylase, an enzyme whose prosthetic group is the vitamin biotin. The biotin–enzyme first undergoes a reaction that results in the attachment of carbon dioxide to biotin; ATP is required and forms ADP and inorganic phosphate (step [62a]).
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…carboxylation reaction is catalyzed by acetyl CoA carboxylase, an enzyme whose prosthetic group is the vitamin biotin. The biotin–enzyme first undergoes a reaction that results in the attachment of carbon dioxide to biotin; ATP is required and forms ADP and inorganic phosphate (step [62a]).
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