X-linked mutation
Quick Summary
An X-linked mutation refers to a genetic alteration located on the X chromosome, one of the two sex chromosomes in humans. These mutations are transmitted through genes on the X chromosome, which carries numerous genes that determine various traits, including some diseases.
Key characteristics of X-linked inheritance include:
* No father-to-son transmission: Since sons inherit the Y chromosome from their father, they cannot receive an X-linked gene from him.
* Carrier females: A female with one copy of the mutated gene has a 50% chance of passing it to each child. Her sons will manifest the trait, while her daughters will be carriers.
* Male expression: Males, having only one X chromosome, will display the trait if they inherit the mutated gene. This is because there is no corresponding gene on the Y chromosome to counteract its effects.
Common X-linked conditions include hemophilia, red-green color blindness, and Duchenne muscular dystrophy.1234
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