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Which three tissue layers form the wall of the uterus?

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The wall of the uterus is composed of three distinct tissue layers:

  • Perimetrium (Serous coat): The outermost layer, which consists of a serous membrane of peritoneum that partially covers the organ.1
  • Myometrium: The middle layer, which comprises the bulk of the uterine wall. It is a thick, firm layer of smooth muscle fibers arranged in longitudinal, circular, and oblique directions.12
  • Endometrium: The innermost layer, which is a mucous membrane that lines the uterine cavity. This layer undergoes significant cyclical changes throughout a woman's reproductive life, including those associated with the menstrual cycle and pregnancy.12