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Treponema pallidum is a spirochete bacterium that causes syphilis, a systemic disease that is typically sexually transmitted. This slender, coiled bacterium requires moisture to survive and reproduces within the body's tissues, persisting for the lifetime of an infected person unless treated. Syphilis can also be transmitted from an infected mother to her fetus.1

While venereal syphilis is sexually transmitted, related infections known as treponematosis are not and are localized in warmer regions with less access to healthcare. Penicillin is an effective treatment for syphilis, killing the spirochetes. Untreated syphilis progresses through primary, secondary, and latent stages, potentially leading to late-stage complications affecting various body systems, including the cardiovascular and nervous systems. A rare neurologic form of tertiary syphilis, tabes dorsalis, involves sensory deficits and loss of coordination.12

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  1. syphilis
  2. tabes dorsalis
  3. syphilis test

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