ā¦divided into two general subpopulationsāTH1 and TH2 cellsāthat have significantly different chemistry and function. These populations can be distinguished by the cytokines they secrete. TH1 cells primarily produce the cytokines gamma interferon, tumor necrosis factor-beta, and interleukin-2 (IL-2), while TH2 cells mainly synthesize the interleukins IL-4, IL-5, IL-6, IL-9,
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