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T-cell lymphoma is a type of lymphoma, which is a cancer of the lymphatic system. Lymphomas typically begin in the lymph nodes or lymphoid tissues in organs like the lungs, spleen, or skin.

Lymphomas are broadly categorized into Hodgkin disease and non-Hodgkin lymphoma. T-cell lymphoma falls under the non-Hodgkin category. These cancers arise when lymphocytes, a type of white blood cell, undergo malignant transformation. This transformation means the cells are no longer regulated by normal growth processes and proliferate uncontrollably, forming a tumor. The specific type of lymphoma can be identified by characteristic surface antigens on the transformed cells, which aids in determining prognosis and treatment.123

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