Sabin vaccine
Quick Summary
The Sabin vaccine is an oral polio vaccine developed by Albert Sabin. It contains live, weakened strains of the poliovirus and is administered orally. This differs from the Salk vaccine, which uses killed virus and is given by injection. The Sabin vaccine stimulates both systemic and local immune responses, and its weakened virus is shed through feces, indirectly immunizing others. While highly effective, in rare cases, the live virus in the Sabin vaccine can cause vaccine-derived polioviruses or vaccine-associated paralytic poliomyelitis. Due to these risks, some countries have transitioned back to the inactivated poliovirus vaccine (IPV).1234
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polio vaccineHistorical developments…oral poliovirus vaccine (OPV) or Sabin vaccine, named for American physician and microbiologist Albert Sabin, was developed. OPV contains live attenuated (weakened) virus and is given orally. The Sabin vaccine was preceded by a live oral vaccine developed and successfully tested by Polish-born virologist Hilary Koprowski in the early 1950s.…
Read More…oral poliovirus vaccine (OPV) or Sabin vaccine, named for American physician and microbiologist Albert Sabin, was developed. OPV contains live attenuated (weakened) virus and is given orally. The Sabin vaccine was preceded by a live oral vaccine developed and successfully tested by Polish-born virologist Hilary Koprowski in the early 1950s.…
Read More- polioTreatment and vaccination
…oral poliovirus vaccine (OPV), or Sabin vaccine, named for its inventor, Albert Sabin. IPV, based on killed, or inactivated, poliovirus serotypes 1, 2, and 3, was the first vaccine to break the scourge of polio epidemics in the 1950s. It is administered by injection and circulates through the bloodstream, where…
Read More…oral poliovirus vaccine (OPV), or Sabin vaccine, named for its inventor, Albert Sabin. IPV, based on killed, or inactivated, poliovirus serotypes 1, 2, and 3, was the first vaccine to break the scourge of polio epidemics in the 1950s. It is administered by injection and circulates through the bloodstream, where…
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infectious diseaseImmunization…attenuated, oral polio virus (Sabin vaccine) induces both local gastrointestinal and systemic antibody production; thus, immunization by mouth is preferred.
Read More…attenuated, oral polio virus (Sabin vaccine) induces both local gastrointestinal and systemic antibody production; thus, immunization by mouth is preferred.
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virusPrevention…types, and the “live” (Sabin) vaccine, composed of genetically attenuated viruses of the three types. In developed countries these vaccines, which were introduced in the 1950s, have lowered the incidence of paralysis resulting from polio. The disease still occurs in developing countries and recurs in some developed countries where…
Read More…types, and the “live” (Sabin) vaccine, composed of genetically attenuated viruses of the three types. In developed countries these vaccines, which were introduced in the 1950s, have lowered the incidence of paralysis resulting from polio. The disease still occurs in developing countries and recurs in some developed countries where…
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