NADH dehydrogenase

enzyme

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July 1, 2026

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NADH dehydrogenase is an enzyme that plays a crucial role in cellular respiration. It is involved in the process of oxidative phosphorylation, which generates ATP, the energy currency of the cell.1

NADH dehydrogenase is part of the respiratory chain, a series of electron carriers within the mitochondria. This enzyme facilitates the transfer of electrons from NADH (the reduced form of NAD+) to other carriers in the chain. This transfer is a key step in releasing energy that is then used to synthesize ATP.123

The enzyme itself has a coenzyme, FMN (flavin mononucleotide), and is involved in the dehydrogenation reaction where hydrogen atoms or electrons are removed from substrates. This process is essential for efficiently extracting energy from nutrients.1

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metabolism
The nature of the respiratory chain
…by an enzyme known as NADH dehydrogenase; the enzyme has as its coenzyme FMN. There is no corresponding NADPH dehydrogenase in mammalian mitochondria; instead, the reducing equivalents of NADPH + H⁺ are transferred to NAD⁺ in a reaction catalyzed by a transhydrogenase enzyme, with the products being reduced NADH +…
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…by an enzyme known as NADH dehydrogenase; the enzyme has as its coenzyme FMN. There is no corresponding NADPH dehydrogenase in mammalian mitochondria; instead, the reducing equivalents of NADPH + H⁺ are transferred to NAD⁺ in a reaction catalyzed by a transhydrogenase enzyme, with the products being reduced NADH +…
Read More