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The Lutheran blood group system is a classification of human blood based on the presence of Lutheran antigens on red blood cells. There are 19 known Lutheran antigens, all originating from variations in the BCAM gene. The system uses two codominant alleles, Lua and Lub. While the Lu(a+b-) and Lu(a+b+) phenotypes occur at varying frequencies, the Lu(a-b+) phenotype is the most common. The Lu(a-b-) phenotype is extremely rare. Though present in fetuses, Lua rarely causes transfusion reactions or erythroblastosis fetalis. The Lewis blood group system is another classification based on Lewis (Le) antigens, which are closely associated with the secretor and ABO blood group systems.12

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