Laron dwarfism

medical disorder

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Last updated

July 17, 2026

Quick Summary

Laron dwarfism is a rare, inherited condition characterized by the body's inability to respond to growth hormone (GH). Unlike other forms of dwarfism caused by insufficient GH production, individuals with Laron dwarfism have high levels of GH. However, their bodies have defective GH receptors, which prevents GH from stimulating the liver and other tissues to produce insulin-like growth factor 1 (IGF-1). This lack of IGF-1 leads to significantly impaired growth, resulting in abnormally short stature. The condition is also known as GH insensitivity.1

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growth hormone
Growth hormone deficiency
This disorder is known as Laron dwarfism and is characterized by abnormal GH receptors, resulting in decreased GH-stimulated production of IGF-1 and poor growth. Serum GH concentrations are high because of the absence of the inhibitory action of IGF-1 on GH secretion. Dwarfism may also be caused by insensitivity of…
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This disorder is known as Laron dwarfism and is characterized by abnormal GH receptors, resulting in decreased GH-stimulated production of IGF-1 and poor growth. Serum GH concentrations are high because of the absence of the inhibitory action of IGF-1 on GH secretion. Dwarfism may also be caused by insensitivity of…
Read More