How does the vesicular transport model explain movement through the Golgi apparatus?

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Diagram of the Golgi apparatus showing its stacked, curved membranes with labeled parts including cisternae, cis face, trans face, lumen, and various vesicles involved in cellular transport and secretion. — Golgi apparatus A membrane-bound organelle of eukaryotic cells, the Golgi apparatus is made up of a series of flattened, stacked pouches called cisternae that function as a series of compartments that progressively refine and direct cellular products to their proper destinations. .

The vesicular transport model proposes that the Golgi apparatus consists of stationary cisternae. According to this model, proteins and lipids move through the organelle by budding off from one cisterna in vesicles and subsequently fusing with the membrane of the next cisterna in the sequence.

Additionally, this model suggests that budding vesicles are utilized to transport molecules in a retrograde direction, moving them back toward the endoplasmic reticulum. This perspective contrasts with the cisternal maturation model, which views the Golgi as a more dynamic structure where the cisternae themselves progress and mature from the cis face to the trans face.1