How do sweet, bitter, and umami receptors detect chemicals in food?

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In humans and other vertebrates, the detection of sweet, bitter, and umami tastes relies on specialized taste receptor cells located within taste buds on the tongue, palate, and throat.12

These sensations are mediated by specific protein molecules—the receptors—situated on the surface of these specialized cells. When chemicals in food come into contact with the microvilli of these receptor cells, they bind to these receptors. This binding interaction triggers the receptor cells to produce electrical signals, which are then transmitted to the brain via afferent sensory [neurons].31