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How do proteins enter the cis face of the Golgi apparatus?
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Golgi apparatus
A membrane-bound organelle of eukaryotic cells, the Golgi apparatus is made up of a series of flattened, stacked pouches called cisternae that function as a series of compartments that progressively refine and direct cellular products to their proper destinations. .
Proteins enter the cis face of the Golgi apparatus through the following process:
- Packaging: Proteins synthesized in the rough endoplasmic reticulum are packaged into small, membrane-bounded transport vesicles within the transitional region of the ER.1
- Transport: These vesicles move through the cytoplasm toward the Golgi apparatus, often migrating along microtubules through a specialized trafficking compartment known as the vesicular-tubular cluster.2
- Fusion: Upon reaching the Golgi, clusters of these fused vesicles merge with the membrane of the cis face. This fusion delivers the vesicle contents into the lumen of the cis face cisterna, where the proteins are then received by the cis Golgi network for further processing and sorting.2