Britannica
Sources used in this answer
How do Leydig cells contribute to the male reproductive system?
Created from Britannica articles
using AI.
AI can make mistakes, so verify using Britannica articles.
human reproductive system
Organs and structures of the male and female reproductive systems.
Leydig cells, also known as interstitial cells, are located in the connective tissue between the seminiferous tubules within the testes. They play a vital role in the male reproductive system primarily by producing testosterone, the principal male androgen.12
Their contributions include:
- Hormone Production: Under the stimulation of luteinizing hormone (LH) from the pituitary gland, Leydig cells secrete testosterone. This process becomes markedly active at [puberty].12
- Support of Spermatogenesis: Through a paracrine function, the testosterone produced by Leydig cells acts on adjacent seminiferous tubules to stimulate spermatogenesis, the process of sperm formation.3
- Development of Male Characteristics: Testosterone released into the bloodstream stimulates the development of male accessory sex glands (such as the prostate gland and seminal vesicles) and secondary sex characteristics, including increased muscle mass, facial hair growth, and voice deepening.423
These cells are essential for both the maturation of sperm and the maintenance of masculine physiological traits.42