How can oral contraceptives prevent ovulation?

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Oral contraceptives function primarily by utilizing synthetic steroid hormones—typically a combination of estrogen and progestin, or progestin alone—to disrupt the hormonal signals that regulate the menstrual cycle.12

Under normal conditions, the pituitary gland releases follicle-stimulating hormone (FSH) and luteinizing hormone (LH), which stimulate the ovaries to produce estrogen and trigger ovulation. Oral contraceptives prevent this process through a mechanism known as negative feedback:12

  • Suppression of Hormones: The synthetic hormones in the pill inhibit the pituitary gland from releasing the necessary levels of FSH and LH.12
  • Inhibition of Ovulation: Without the surge of FSH and LH, the ovarian follicle does not mature, and the release of a mature egg is prevented.13

Additionally, progestin-only preparations can further reduce the likelihood of pregnancy by thickening the cervical mucus, which creates a barrier that makes it difficult for sperm to reach the egg.12