HMG-CoA reductase
enzyme
Also known as: 5-hydroxy-3-methylglutaryl-coenzyme A
Quick Summary
HMG-CoA reductase is an enzyme crucial for cholesterol synthesis. It plays a key role in regulating cholesterol metabolism within the body, particularly in the liver.1
This enzyme is the target of statins, a class of drugs used to lower cholesterol levels. By inhibiting HMG-CoA reductase, statins reduce the body's production of cholesterol. High cholesterol levels are a significant risk factor for heart disease, making the regulation of this enzyme and the use of statins medically important.231
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