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H-Y antigen
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H-Y antigen

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Quick Summary

The H-Y antigen is a cell surface molecule involved in human sex determination. It is produced by a gene on the Y chromosome and stimulates the development of male reproductive organs. The H-Y antigen is a key factor in establishing male gonadal sex.1

While the H-Y antigen is specifically related to male sex determination, the broader concept of human leukocyte antigens (HLAs) refers to a group of antigens encoded by genes in the major histocompatibility complex on chromosome 6. These HLA genes play a crucial role in the immune system's ability to recognize and defend against a wide range of foreign substances. HLA typing is also important in tissue transplantation to ensure compatibility between donor and recipient.2

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2 Britannica Sources
  1. human leukocyte antigen
  2. human genetics - Fertilization , sex determination, and differentiation

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