FMRP

protein

Also known as: fragile-X mental retardation protein

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Last updated

July 17, 2026

Quick Summary

FMRP, or fragile-X mental retardation protein, is a protein crucial for brain development and synapse maturation. The symptoms of fragile-X syndrome, a chromosomal disorder causing intellectual disability, stem from the loss or partial loss of FMRP. This protein is encoded by the FMR1 gene, located on the X chromosome. Mutations in FMR1 lead to an excessive number of DNA triplet repeats, disrupting synapse formation and function. While there is no cure, therapies like physical therapy, speech therapy, and assistive technologies can help affected individuals.1

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fragile-X syndrome
…of a protein known as FMRP (fragile-X mental retardation protein). FMRP plays an important role in the brain, facilitating the development and maturation of synapses (connections) between neurons. Synapses conduct electrical impulses and translate electrical signals to biochemical actions that are fundamental to cognition. It is believed that FMRP exerts…
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…of a protein known as FMRP (fragile-X mental retardation protein). FMRP plays an important role in the brain, facilitating the development and maturation of synapses (connections) between neurons. Synapses conduct electrical impulses and translate electrical signals to biochemical actions that are fundamental to cognition. It is believed that FMRP exerts…
Read More