CHEK2

The CHEK2 gene plays a role in DNA repair and cell cycle regulation. It acts as a tumor suppressor, helping to prevent cells from dividing uncontrollably. When CHEK2 is mutated, its ability to repair DNA damage is hindered, which can increase the risk of developing certain cancers, such as breast, ovarian, and prostate cancer.1

The cell cycle is a series of events cells undergo to prepare for division. This process involves growth, DNA replication, and cell division. Proteins and checkpoint systems ensure the cycle progresses correctly, with mechanisms in place to detect and repair DNA damage. If damage is too severe, cells undergo programmed cell death. However, mutations in genes like CHEK2 can disrupt these checkpoints, potentially leading to cancer. Geneticist Stephen J. Elledge's work has shed light on genes involved in cell-cycle regulation and DNA repair, contributing to our understanding of cancer development.23