CD8

biochemistry

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Last updated

July 16, 2026

Quick Summary

CD8 is a glycoprotein found on the surface of cytotoxic T cells, a type of lymphocyte crucial for the immune system. It plays a vital role in cell-mediated immunity by binding to major histocompatibility complex (MHC) class I molecules on antigen-presenting cells. This binding facilitates antigen recognition and activates cytotoxic T cells, enabling them to identify and destroy infected or cancerous cells. CD8 acts as a coreceptor, strengthening the interaction between the T cell and the target cell.12

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immune system
Function of the T-cell receptor
…on their surfaces the coreceptor CD8, which recognizes class I MHC molecules. These accessory receptors add strength to the bond between the T cell and the target cell.
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…on their surfaces the coreceptor CD8, which recognizes class I MHC molecules. These accessory receptors add strength to the bond between the T cell and the target cell.
Read More