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Brunner glands are located in the submucosa of the duodenum, the first part of the small intestine. These glands secrete a fluid containing mucus, bicarbonate, and a weak proteolytic enzyme. Their secretions help lubricate and protect the duodenal lining. The duodenum receives partially digested food from the stomach and begins the absorption of nutrients, particularly iron and calcium. Brunner glands contribute to this process by providing protective secretions.12

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