Bernard-Soulier syndrome

pathology

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June 22, 2026

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Bernard-Soulier syndrome is an inherited bleeding disorder caused by a deficiency of glycoprotein Ib on the platelet membrane. This glycoprotein is essential for normal platelet function. As a result, individuals with Bernard-Soulier syndrome experience a pronounced tendency to bleed. The platelets in this condition are also unusually large. This contrasts with Glanzmann thrombasthenia, another inherited platelet disorder, which is due to a deficiency of glycoprotein IIb–IIIa. Bleeding disorders can stem from inherited or acquired defects in clotting or platelet function, leading to persistent bleeding.12

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blood disease
Disorders of platelet function
Bernard-Soulier syndrome, an inherited disorder associated with a pronounced bleeding tendency, is due to a deficiency of glycoprotein Ib, also necessary for normal platelet function, on the platelet membrane. The platelets in this disease are unusually large. Many other platelet defects exist, but they have…
Read More
Bernard-Soulier syndrome, an inherited disorder associated with a pronounced bleeding tendency, is due to a deficiency of glycoprotein Ib, also necessary for normal platelet function, on the platelet membrane. The platelets in this disease are unusually large. Many other platelet defects exist, but they have…
Read More