ACAM2000

ACAM2000 is a smallpox vaccine approved in the United States in 2007. It is produced using cell-culture techniques, allowing for rapid and large-scale production in case of a smallpox emergency. The vaccine contains live vaccinia virus, a virus closely related to the one that causes smallpox, and provides about 95% effectiveness in preventing infection for three to five years. While generally safe, it can cause mild side effects like fever and headache, and in rare cases, more severe reactions, particularly in individuals with weakened immune systems. Routine smallpox vaccination has been discontinued globally since the eradication of smallpox in 1980.12