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What controversy surrounded the patenting of Banisteriopsis caapi?

In 1986 American entrepreneur Loren Miller patented Da Vine, a variety of Banisteriopsis caapi. This move was opposed by Indigenous communities in South America. The patent was challenged for lack of novelty and is considered an example of biopiracy. Although initially rejected by the U.S. Patent and Trademark Office in 1999, the patent was later reinstated in 2001. The patent expired in 2003, putting the patented B. caapi variety permanently in the public domain.