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Discussion questions

  1. Should medical marijuana be legal? Why or why not? If yes, which jurisdiction(s) should legalize marijuana (federal, state, local)?
  2. Should medical marijuana state laws indicate which medical conditions marijuana is an appropriate medication for? Or should marijuana be regulated by the FDA like other drugs? Explain your answer(s).
  3. Should recreational marijuana be decriminalized while scientists study the marijuana as a medicine? Explain your answer(s).
  4. What questions do you have after reading the debate above? Where might you find answers?
  5. What was the most interesting thing you learned from this debate?
  6. Consider how you felt about the issue before reading this article. After reading the pros and cons on this topic, has your thinking changed? How and why?. If your thoughts have not changed, explain how and why you better understand the other side of the debate.
  7. Push for the position and policies you support by writing local officials, U.S. senators and representatives, or other people in a position to make the change you champion.

Sources

  1. Lester Grinspoon, “History of Cannabis as a Medicine” (August 16, 2005), venicecare.com
  2. Michelle Z. Donahue, “Earliest Evidence for Cannabis Smoking Discovered in Ancient Tombs” (June 12, 2019), nationalgeographic.com
  3. Meng Ren, et al., “The Origins of Cannabis Smoking: Chemical Residue Evidence from the First Millennium BCE in the Pamirs” (June 12, 2019), science.org
  4. Colleen Fisher Tully, “Did Women Use Cannabis as Medicine in Ancient Egypt?” (August 3, 2020), leafly.com
  5. New York Review, “Pot and the Myth of Shen Nung: Erich Goode, Reply by Jerome Groopman” (March 20, 2014), nybooks.com
  6. Jerome Groopman, “Marijuana: The High and the Low” (February 20, 2014), nybooks.com
  7. Jonny Winship, “A Definitive Guide to the History of Medical Cannabis” (November 9, 2018), huckmag.com
  8. Joshua J. Mark, “Ancient Egyptian Medical Texts” (February 21, 2017), worldhistory.org
  9. Emily Ledger, “Cannabis Use in the Ancient World: Ancient Egypt” (January 5, 2021), canex.co.uk
  10. Weedmaps, “History of Cannabis” (accessed October 20, 2022), herb.delivery
  11. Bill Weinberg, “A Brief History of Marihuana in Mexico” (May 22, 2018), freedomleaf.com
  12. Kushka, “History of Cannabis in Mexico” (September 27, 2020), dinafem.org
  13. David McDonald, ”The Racist Roots of Marijuana Prohibition” (April 11, 2017), fee.org
  14. S.P.H. Alexander, et al, “Editorial” (June 2010), British Journal of Pharmacology
  15. David Moye, “Lawmaker Says Black People Can’t Handle Marijuana Because of ’Genetics’” (September 1, 2018), huffingtonpost.co.uk
  16. Amy Tikkanen, “Why Is Marijuana Illegal in the U.S.?” (April 15, 2019), britannica.com
  17. Gov.uk, “Drugs Penalties” (accessed October 20, 2022), gov.uk
  18. U.K. Department of Health, “Categories Drugs Are Separated into for Control Purposes” (accessed October 20, 2022), health-ni.gov.uk
  19. Danielle Ivory, et al, “Cannabis Poisonings Are Rising, Mostly Among Kids” (August 10, 2025), nytimes.com
  20. Winfried Meissner, et al, “VER-01 Shows Enhanced Gastrointestinal Tolerability, Superior Pain Relief, and Improved Sleep Quality Compared to Opioids in Treating Chronic Low Back Pain: A Randomized Phase 3 Clinical Trial” (September 30, 2025), Pain and Therapy, link.springer.com
  21. Pew Research Center, “Most Americans Favor Legalizing Marijuana for Medical, Recreational Use” (March 26, 2024), pewresearch.org
  22. Peter Grinspoon, “Medical Marijuana” (April 10, 2020), health.harvard.edu
  23. Caitlin Isles, “7 Potential Health Benefits of Cannabis” (September 22, 2021), jwu.edu
  24. Khalid A. Jadoon, Garry D. Tan, and Saoirse E. O’Sullivan, “A Single Dose of Cannabidiol Reduces Blood Pressure in Healthy Volunteers in a Randomized Crossover Study” (June 15, 2017), JCI Insight
  25. Wei Xiong, et al., “Cannabinoids Suppress Inflammatory and Neuropathic Pain by Targeting α3 Glycine Receptors” (June 4, 2012), Journal of Experimental Medicine
  26. Gustavo Gonzalez-Cuevas, et al., “Unique Treatment Potential of Cannabidiol for the Prevention of Relapse to Drug Use: Preclinical Proof of Principle” (March 22, 2018), Neuropsychopharmacology
  27. Esther M. Blessing, et al., “Cannabidiol as a Potential Treatment for Anxiety Disorders” (October 2015), Neurotherapeutics
  28. Vicente MartĂ­nez, et al., “Cannabidiol and Other Non-Psychoactive Cannabinoids for Prevention and Treatment of Gastrointestinal Disorders: Useful Nutraceuticals?” (April 2020), International Journal of Molecular Sciences
  29. Alessandra Morano, et al., “Cannabinoids in the Treatment of Epilepsy: Current Status and Future Prospects” (February 2020), Neuropsychiatric Disease Treatment
  30. The American Cancer Society Medical and Editorial Content Team, “Marijuana and Cancer” (August 2, 2022), cancer.org
  31. National Institutes of Health, National Institute on Drug Abuse, “Cannabis (Marijuana) Research Report: Is Marijuana Safe and Effective as Medicine?” (July 2020), nida.nih.gov
  32. Greg Miller, “Could Pot Help Solve the U.S. Opioid Epidemic?” (November 3, 2018), science.org
  33. Stephanie Lake, M. Eugenia SocĂ­as, and M.-J. Milloy, “Evidence Shows That Cannabis Has Fewer Relative Harms than Opioids” (February 18, 2020), Canadian Medical Association Journal
  34. Christina Palmer,” Can Marijuana Be as Effective as Medications?” (June 1, 2021), goodrx.com
  35. Matthias Karst et al, “Full-Spectrum Extract from Cannabis Sativa DKJ127 for Chronic Low Back Pain: A Phase 3 Randomized Placebo-Controlled Trial” (September 29, 2025), Nature Medicine, nature.com
  36. Kevin M Takakuwa and Raquel M Schears, “Emergency Medicine Physicians Would Prefer Using Cannabis Over Opioids for First-Line Treatment of a Medical Condition if Provided With Medical Evidence: A National Survey” (November 2021), Cureus
  37. U.S. Customs and Border Protection, “Did You Know... Marijuana Was Once a Legal Cross-Border Import?” (December 20, 2019), cbp.gov
  38. Sarah C. Hull, “Op-Ed: We Should Not Allow a Marijuana Free-for-All” (January 15, 2021), medpagetoday.com
  39. George Sam Wang, “Pediatric Concerns Due to Expanded Cannabis Use: Unintended Consequences of Legalization” (March 2017), Journal of Medical Toxicology
  40. National Institutes of Health, National Institute on Drug Abuse, “Cannabis (Marijuana) DrugFacts” (December 2019), nida.nih.gov
  41. Claire McCarthy, “Legalizing Marijuana Not Good for Kids: AAP Policy Explained” (March 23, 2022), healthychildren.org
  42. Kevin Osterhoudt, “Edible Marijuana Dangers: How Parents Can Prevent THC Poisoning” (May 16, 2022), healthychildren.org
  43. CDC, “​​Addiction (Marijuana or Cannabis Use Disorder)” (October 19, 2020), cdc.gov
  44. Emily Sohn, “Weighing the Dangers of Cannabis” (August 28, 2019), nature.com
  45. Maureen Meehan, “U.S. Surgeon General Vivek Murthy: There Is ‘No Value’ To Incarcerating People For Cannabis Use” (July 19, 2021), yahoo.com
  46. NORML, “Decriminalization” (accessed October 26, 2022), norml.org
  47. Jen Christensen and Sandee LaMotte, “Number of Young Children Who Accidentally Ate Cannabis Edibles Jumped 1,375% in Five Years, Study Finds” (January 5, 2023), cnn.com
  48. Julia Milzer, “Largest Study Ever Done on Cannabis and Brain Function Finds Impact of Working Memory” (February 6, 2025), news.cuanschutz.edu
  49. Joshua L. Gowin, er al., “Brain Function Outcomes of Recent and Lifetime Cannabis Use” (January 28, 2025), jamanetwork.com
  50. Michael Hsu, et. al, “Therapeutic Use of Cannabis and Cannabinoids” (November 26, 2025), jamanetwork.com
  51. Cleveland Clinic, “Cannabis Use Disorder,” my.clevelandclinic.org (accessed December 16, 2025)
  52. White House, “Increasing Medical Marijuana and Cannabidiol Research” (December 18, 2025), whitehouse.gov
  53. Scott L. Miley, “U.S. Surgeon General Jerome Adams Supports Studying Medical Marijuana” (December 1, 2017), newsandtribune.com
  54. CBS News, “New Surgeon General Dr. Vivek Murthy: Measles Vaccine Is Safe and Effective” (February 4, 2015), CBS News
  55. Deborah Solomon, “Doctor’s Orders” (January 7, 2011), nytimes.com
  56. Richard Carmona, “Clearing the Air about Marijuana” (November 4, 2016), medium.com
  57. Deborah Solomon, “Health-Conscious” (June 19, 2005), nytimes.com
  58. Patti Singer, “Former Surgeon General on Guns, Drugs, Money for Zika” (September 12, 2016), democratandchronicle.com
  59. David Satcher, “Schedules of Controlled Substances: Addition of Gamma-Hydroxybutyric Acid to Schedule I” (March 13, 2000) federalregister.gov
  60. M. Joycelyn Elders, “Myths about Medical Marijuana” (March 26, 2004), Providence Journal
  61. C. Everett Koop, “Surgeon General’s Advisory on Marijuana” (draft version), (1982), profiles.nlm.nih.gov
  62. “Government OKs Marijuana Pill Use for Certain Cancer Patients” (September 11, 1980), San Bernardino County Sun
  63. Marijuana Policy Project’s (MPP), “Medical Marijuana Endorsements and Statements of Support” (accessed January 27, 2009), mpp.org
  64. Michael Hsu, et al, “Therapeutic Use of Cannabis and Cannabinoids: A Review” (November 26, 2025), jamanetwork.com
  65. Wilhelm Storck, “Cardiovascular Risk Associated with the Use of Cannabis and Cannabinoids: A Systematic Review and Meta-Analysis” (June 17, 2025), Heart, heart.bmj.com
  66. Benjamin H. Han, et al., “Trends in Past-Month Cannabis Use Among Older Adults” (June 2, 2025), JAMA Internal Medicine, jamanetwork.com
  67. Daniel T Myran, et al., “Risk of Dementia in Individuals With Emergency Department Visits or Hospitalizations Due to Cannabis” (June 1, 2025), JAMA neurology, pubmed.ncbi.nlm.nih.gov
  68. Leila Mohammadi, et al., “Association of Endothelial Dysfunction With Chronic Marijuana Smoking and THC-Edible Use” (May 28, 2025), JAMA Cardiology, jamanetwork.com
  69. Stanford Medicine, “Endothelial Dysfunction” (accessed July 25, 2025), stanfordheathcare.org
  70. Vira Pravosud, et al., “Cannabis Use Among Older Adults” (May 14, 2025), JAMA Network Open, jamanetwork.com
  71. Zerleen S. Quader, et al., “Routes of Marijuana Use — Behavioral Risk Factor Surveillance System, 22 U.S. States and Two Territories, 2022” (April 10, 2025), Morbidity and Mortality Weekly Report, cdc.gov
  72. Daniel T. Myran, et al., “Cannabis Use Disorder Emergency Department Visits and Hospitalizations and 5-Year Mortality” (February 6, 2025), JAMA Network Open, jamanetwork.com
  73. Daniel T. Myran, et al., “Changes in Incident Schizophrenia Diagnoses Associated With Cannabis Use Disorder After Cannabis Legalization” (February 4, 2025), JAMA Network Open, jamanetwork.com
  74. Shweta Paulraj, et al., “Arrhythmias and Cannabis Use: A Comprehensive Overview” (January 2025), Heart Rhythm O2, sciencedirect.com
  75. Silvia Perez-Vilar, et al., “State Cannabis Legalization and Trends in Cannabis-Related Disorders in US Older Adults, 2017 to 2022” (June 18, 2024), JAMA Network Open, jamanetwork.com
  76. Mona M Geweda, et al., “Evaluation of Dispensaries’ Cannabis Flowers for Accuracy of Labeling of Cannabinoids Content” (March 9, 2024), Journal of Cannabis Research, pmc.ncbi.nlm.nih.gov
  77. Abra M. Jeffers, “Association of Cannabis Use With Cardiovascular Outcomes Among U.S. Adults” (February 28, 2024), JAHA: Journal of the American Heart Association, ahajournals.org
  78. Julia Chambers, et al., “Perceptions of Safety of Daily Cannabis vs Tobacco Smoking and Secondhand Smoke Exposure, 2017-2021” (August 1, 2023), JAMA Network Open, pubmed.ncbi.nlm.nih.gov
  79. Carsten Hjorthþj, et al., “Association Between Cannabis Use Disorder and Schizophrenia Stronger in Young Males than in Females” (May 5, 2023), Psychological Medicine, cambridge.org
  80. National Institutes of Health, “Young Men at Highest Risk of Schizophrenia Linked with Cannabis Use Disorder” (May 4, 2023), nih.gov
  81. Benjamin H Han et al., “Trends in Emergency Department Visits Associated with Cannabis Use Among Older Adults in California, 2005–2019” (April 2023), Journal of the American Geriatric Society, pubmed.ncbi.nlm.nih.gov
  82. Benjamin H. Han, et al., “Decreasing Perceived Risk of Regular Cannabis Use Among Older Adults in the United States from 2015 to 2019” (May 26, 2021), Journal of the American Geriatric Society, pmc.ncbi.nlm.bih.gov
  83. Hannah Zwiebel, et al, “Accidental Cannabis Ingestion in Young Children” (March 2025), Canadian Family Physician, pmc.ncbi.nlm.nih.gov
  84. Jane Metrik, et al, “Acute Effects of Cannabis on Alcohol Craving and Consumption: A Randomized Controlled Crossover Trial” (November 18, 2025), The American Journal of Psychiatry, psychiatryonline.org
  85. Pablo Martínez, et al, “Health Service Use Among Young Adults With a History of Adolescent Cannabis Use” (October 28, 2025), JAMA Network Open, jamanetwork.com
  86. Joshua L. Gowin, et al, “Brain Function Outcomes of Recent and Lifetime Cannabis Use” (January 28, 2025), JAMA Network Open, jamanetwork.com
  87. Kelly C. Young-Wolff, et al. “Adolescent Cannabis Use and Risk of Psychotic, Bipolar, Depressive, and Anxiety Disorders” (February 20, 2026), JAMA Health Forum, jamanetwork.com
  88. Committee on Clinical Consensus–Obstetrics, “Cannabis Use During Pregnancy and Lactation” (October 2025), acog.org
  89. American College of Obstetricians & Gynecologists, “ACOG Clinical Consensus No. 10: Cannabis Use During Pregnancy and Lactation” (October 2025), Obstetrics & Gynecology, journals.lww.com
  90. E. Joseph Brand, Zhongzhen Zhao, “Cannabis in Chinese Medicine: Are Some Traditional Indications Referenced in Ancient Literature Related to Cannabinoids?” (March 10, 2017), pmc.ncbi.nlm.nih.gov
  91. Max Matza, “Trump Administration Reclassifies Cannabis as Less Dangerous” (April 23, 2026), bbc.com
  92. Todd Blanche (April 26, 2026), x.com
  93. Office of Public Affairs, “Justice Department Places FDA-Approved Marijuana Products and Products Containing Marijuana Subject to a Qualifying State-issued License in Schedule III, Strengthening Medical Research While Maintaining Strict Federal Controls” (April 23, 2026), justice.gov