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Ypsilanti, city, Washtenaw county, southeastern Michigan, U.S. It lies along the Huron River just east of Ann Arbor. The settlement of Woodruff’s Grove was established on the Huron River in 1823, near the site of a French trading post (1809–19). In 1824 surveying crews for a proposed Detroit-Chicago highway placed the road’s Huron River crossing nearly 1 mile (1.6 km) north of Woodruff’s Grove, and the following year a trio of local landowners combined their...