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Wellsburg, city, seat (1797) of Brooke county, in the northern panhandle of West Virginia, U.S. It lies along the Ohio River, about 15 miles (24 km) north of Wheeling, West Virginia, and opposite Brilliant, Ohio. Settled in 1772, it was chartered as Charlestown in 1791 but was renamed in 1816 to honour Alexander Wells, an early settler. Boatyards and warehouses sprang up around its river landing. The state’s first glass plant was built there in...