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Shepherdstown, town, Jefferson county, in the eastern panhandle of West Virginia, U.S., near the Potomac River, about 10 miles (16 km) northwest of Harpers Ferry. One of the state’s oldest towns, it was first settled in the early 18th century by Germans from Pennsylvania. In the 1730s Thomas Shepherd laid out the town, and it was chartered as Mecklenburg in 1762. It was renamed Shepherdstown in 1798 (the name was officially recognized by the state...