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Santiago del Estero, city, capital of Santiago del Estero provincia (province), northwestern Argentina, and the oldest continuous settlement in the country. It was founded in 1553 by Spaniards coming from Peru, led by Francisco de Aguirre, and it was moved slightly south in 1556 to its present location on the Dulce River. Although the region’s climate is extremely hot and dry, the surrounding irrigated plains produce considerable crops of wheat, cotton, flax, corn (maize), and...