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San Mateo, city, San Mateo county, western California, U.S. It lies on the western shore of San Francisco Bay, 16 miles (26 km) south of the city of San Francisco. Sheltered by hills from ocean wind and fog, San Mateo enjoys a mild maritime climate. The area was first inhabited by Ohlone Indians. A Spanish exploring party (1776) named a creek at the site after St. Matthew, and in 1793 a Spanish mission hospice was...