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Salem, city, seat (1823) of Marion county, south-central Illinois, U.S. It lies about 70 miles (115 km) east of St. Louis, Missouri. It was first settled about 1811, soon after the devastating earthquake along the New Madrid Fault, and quickly became a stop on the stagecoach route from St. Louis to Vincennes, Indiana; Halfway Tavern State Memorial, east of the city, marks the midpoint of the route. Salem was laid out in 1823 and made...