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Redwood City, city, seat (1856) of San Mateo county, California, U.S. It lies on the western shore of San Francisco Bay, at the mouth of Redwood Creek, 25 miles (40 km) south of San Francisco. Originally inhabited by Ohlone Indians, the area in 1800 became part of a Spanish land grant called Rancho de las Pulgas (Spanish: “Ranch of the Fleas”). It was an early port and had shipbuilding, lumber, and tannery industries. The city...