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Prince George’s, county, south-central Maryland, U.S. It consists of a piedmont and plains region bounded by the Patuxent River to the northeast and east and the Potomac River (constituting the border with Virginia) and Washington, D.C., to the west. Prince George’s county is home to Andrews Air Force Base, the National Agricultural Research Center, and the northern part of Cedarville State Forest. The county was created in 1695 and named for Prince George of Denmark,...