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Prairie du Chien, city, seat (1818) of Crawford county, southwestern Wisconsin, U.S. It is considered to be the state’s second oldest settlement (after Green Bay). It lies on the Mississippi River just above the influx of the Wisconsin River, about 100 miles (160 km) west of Madison. Fox, Sauk, and Ho-Chunk Nation (Winnebago) Indians were early inhabitants of the area. In 1673 the French explorers Jacques Marquette and Louis Jolliet traveled from Green Bay down...